Ticlopidine Hydrochloride: A Thienopyridine Adenosine-5'-Diphosphate (ADP) Receptor Antagonist
Ticlopidine hydrochloride, clopidogrel sulfate [
C2556], and prasugrel [
P2024] belong to the same family of thienopyridine adenosine-5'-diphosphate (ADP) receptor antagonists. Although ticlopidine was discovered more than 30 years ago, it was only recently that the mechanism of action of ADP-receptor antagonists was characterized in detail. They achieve antiplatelet effects by inhibiting the binding of ADP to its platelet P2Y
12 ADP receptor. They are prodrugs and are then converted to thiol-containing active metabolites through a corresponding thiolactone.