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CAS RN: 138982-67-9 | Product Number: Z0032
Ziprasidone Hydrochloride Monohydrate
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Purity: >98.0%(HPLC)
Synonyms:
- 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one Hydrochloride Monohydrate
Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
£21.00
|
1 | 12 |
|
| 250MG |
£61.00
|
3 | 9 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | Z0032 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__1ClN__4OS·HCl·H__2O = 467.41 |
| Physical State (20 deg.C) | Solid |
| CAS RN | 138982-67-9 |
| Related CAS RN | 122883-93-6&146939-27-7 |
| Reaxys Registry Number | 13262593 |
| PubChem Substance ID | 253661772 |
| Merck Index (14) | 10171 |
| MDL Number | MFCD00921885 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 %(calcd.on anh.substance) |
| Water | 3.7 to 5.0 % |
Properties (reference)
GHS
Related Laws:
| RTECS# | NM3241200 |
Transport Information:
| HS Number | 2934208090 |
Application
Ziprasidone: A Selective Antagonist at the Dopamine D2, Serotonin 5HT2A, and 5HT1D Receptors
Ziprasidone hydrochloride monohydrate is a benzisothiazolyl piperazine-type atypical antipsychotic that shares the serotonin2A/dopamine2 (5-HT2A/D2) profile of the atypical antipsychotics. Ziprasidone functioned as a selective antagonist at the D2, 5HT2A, and 5HT1D receptors, and also as an agonist at the 5HT1A receptor. Ziprasidone is hepatically metabolized by aldehyde oxidase and cytochrome P450 3A4 (CYP3A4). (The product is for research purpose only.)
References
- Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity
- 5-HT1A receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex
- Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile
- Ziprasidone Metabolism, Aldehyde Oxidase, and Clinical Implications (a review)
- Development and validation of a rapid RP-HPLC method for the estimation of Ziprasidone Hydrochloride Monohydrate in bulk and its capsule dosage forms
PubMed Literature
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