text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

Sulfur-Transfer Reagents for Synthesis of Oligonucleotide Phosphorothioates

DNA and RNA phosphorothioates have attracted attention as novel therapeutic agents through antisense mechanism of action and because of their nuclease resistance.1) Beaucage reagent (1),2) bis(phenylacetyl) disulfide (2)3) and xanthane hydride (3)4,5) are widely used as sulfur-transfer reagents for the synthesis of oligonucleotide phosphorothioates via the phosphoramidite method. In particular, 3 has the advantages that it does not yield oxidants leading to side reactions and generating toxic substances such as carbon disulfide or cyanamide, as byproducts.