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CAS RN: 1024-99-3 | Product Number: I1154
5-Iodouridine
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Purity: >97.0%(HPLC)
Synonyms:
- 2,4-Dihydroxy-5-iodo-1-β-D-ribofuranosylpyrimidine
- 1-[(2R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-iodopyrimidine-2,4(1H,3H)-dione
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
€134.00
|
4 | 22 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | I1154 |
Purity / Analysis Method 
|
>97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__1IN__2O__6 = 370.10 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 1024-99-3 |
| Reaxys Registry Number | 33665 |
| MDL Number | MFCD01114233 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation | -21.0 ～ -25.0 deg(C=1, water) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 204 °C |
GHS
Related Laws:
| EC Number | 213-833-1 |
Transport Information:
| HS Number | 2934999090 |
Application
5-Iodouridine: A Starting Compound for the Synthesis of 5-Substituted Pyrimidine Nucleosides
5-Iodouridine, a pyrimidine nucleoside, is used as a starting compound for the synthesis of 5-substituted pyrimidine nucleosides, which has been shown to have biological properties such as antibacterial and antiviral activities.1-3) In addition, there are reported that 5-halogenated nucleosides, including 5-iodouridine, are incorporated into the DNA of replicating cells to facilitate DNA single-strand breaks and intra- or inter-strand crosslinks upon UV irradiation.4)
References
- 1) Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides
- 2) Synthesis and antiviral antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine
- 3) Synthesis and in vitro antiviral activity of lipophilic pyrimidine nucleoside/carborane conjugates
- 4) Dehalogenation of Halogenated Nucleobases and Nucleosides by Organoselenium Compounds
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