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CAS RN: 70918-00-2 | Product Number: P1836
2-(1-Piperazinylcarbonyl)-1,4-benzodioxane
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Purity: >95.0%(GC)(T)
Synonyms:
- 1-[(1,4-Benzodioxan-2-yl)carbonyl]piperazine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€89.00
|
1 | 5 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P1836 |
Purity / Analysis Method 
|
>95.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__3H__1__6N__2O__3 = 248.28 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Moisture Sensitive |
| CAS RN | 70918-00-2 |
| Reaxys Registry Number | 815128 |
| PubChem Substance ID | 125307580 |
| SDBS (AIST Spectral DB) | 52913 |
| MDL Number | MFCD01837119 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 95.0 % |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 103.0 to 107.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 105 °C |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2933599590 |
Application
A Synthetic Intermediate of Doxazosin Mesylate and Quinolone Antimicrobials
This product and its hydrochloride [P1890] have been used as synthetic intermediates of doxazosin mesylate [D4126], adrenoceptor antagonist.1,2) In addition, this product has been also used for the synthesis of quinolone antimicrobials, including ofloxacin [O0403].3,4)
References
- 1) 2,4-Diamino-6,7-dimethoxyquinazolines. 1. 2-[4-(1,4-Benzodioxan-2-ylcarbonyl)piperazin-1-yl] derivatives as α1-adrenoceptor antagonists and antihypertensive agents
- S. F. Campbell, M. J. Davey, J. D. Hardstone, B. N. Lewis, M. J. Palmer, J. Med. Chem. 1987, 30, 49.
- 2) Practical chemical and enzymatic technologies for (S)-1,4-benzodioxan-2-carboxypiperizine intermediate in the synthesis of (S)-doxazosin mesylate
- 3) Synthesis and antimycobacterial activities of novel 6-nitroquinolone-3-carboxylic acids
- 4) Novel ofloxacin derivatives: Synthesis, antimycobacterial and toxicological evaluation
PubMed Literature
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