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CAS RN: 5786-21-0 | Product Number: C2547

Clozapine


Purity: >98.0%(GC)(T)
Synonyms:
  • 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Documents:
100MG
¥999.00
5   1   14  
1G
¥4,720.00
1   1   ≥20 

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Product Number C2547
Purity / Analysis Method >98.0%(GC)(T)
Molecular Formula / Molecular Weight C__1__8H__1__9ClN__4 = 326.83  
Physical State (20 deg.C) Solid
CAS RN 5786-21-0
Reaxys Registry Number 764984
PubChem Substance ID 135726987
Merck Index (14) 2423
MDL Number

MFCD00153785

Specifications
Appearance Light yellow to Amber to Dark green powder to crystal
Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 183.0 to 187.0 °C
Properties (reference)
Melting Point 185 °C
Solubility in water Insoluble
Solubility (soluble in) Acetone,Chloroform,Methanol
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# HP1750000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
Customs Control Conditions (Q)
Application
Clozapine: A Dibenzodiazepine Agent with Effects on Various Receptors

Clozapine is a dibenzodiazepine “atypical” antipsychotic agent. The precise mechanism of actions is not fully understood. However, it has been reported that the therapeutic efficacy of clozapine is mediated through antagonism of the serotonin type 2A (5-HT2A) receptors. Clozapine also act as an antagonist at adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors. (The product is for research purpose only.)

References


Application
HDAC2 may be a New Target for Schizophrenia Treatment
References

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

M. Kurita, T. Holloway, A. García-Bea, A. Kozlenkov, A. K. Friedman, J. L. Moreno, M. Heshmati, S. A. Golden, P. J. Kennedy, N. Takahashi, D. M. Dietz, G. Mocci, A. M. Gabilondo, J. Hanks, A. Umali, L. F. Callado, A. L. Gallitano, R. L. Neve, L. Shen, J. D. Buxbaum, M.-H. Han, E. J. Nestler, J. J. Meana, S. J. Russo, J. González-Maeso, Nat. Neurosci. 2012, 15, 1245.


PubMed Literature


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