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CAS RN: 87233-62-3 | Product Number: E0936

Emedastine Difumarate


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 1-(2-Ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole Difumarate
Documents:
1G
¥2,655.00
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Product Number E0936
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__7H__2__6N__4O·2C__4H__4O__4 = 534.57  
Physical State (20 deg.C) Solid
CAS RN 87233-62-3
Related CAS RN 87233-61-2
PubChem Substance ID 160871379
Merck Index (14) 3557
MDL Number

MFCD00923844

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Purity(Neutralization titration) min. 98.0 %
Melting point 147.0 to 151.0 °C
Properties (reference)
Melting Point 149 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
RTECS# DD8870000
Transport Information:
Customs Control Conditions (Q)
Application
Studis on Antihistaminic Action of Emedastine
References

Inhibition of histamine-induced human conjunctival epithelial cell responses by ocular allergy drugs

J. M. Yanni, L. K. Weimer, N. A. Sharif, S. X. Xu, D. A. Gamache, J. M. Spellman, Arch. Ophthalmol. 1999, 117, 643.

Histamine-stimulated cytokine secretion from human conjunctival epithelial cells: inhibition by the histamine H1 antagonist emedastine

L. K. Weimer, D. A. Gamache, J. M. Yanni, Int. Arch. Allergy Immunol. 1998, 115, 288.

Synthesis of 2-(4-substituted-1-piperazinyl)benzimidazoles as H1-antihistaminic agents

R. Iemura, T. Kawashima, T. Fukuda, K. Ito, G. Tsukamoto, J. Med. Chem. 1986, 29, 1178.

Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases

H. Murota, I. Katayama, Expert Opin. Pharmacother. 2009, 10, 1859.


PubMed Literature


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