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CAS RN: 10238-21-8 | Product Number: G0382
Glibenclamide
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Purity: >98.5%(T)(HPLC)
Synonyms:
- 5-Chloro-N-[4-(3-cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
- Glyburide
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 5G |
¥80.00
|
19 | 1 | 21 |
| 25G |
¥160.00
|
1 | 1 | 35 |
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| Product Number | G0382 |
Purity / Analysis Method 
|
>98.5%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__8ClN__3O__5S = 494.00 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 10238-21-8 |
| Reaxys Registry Number | 2230085 |
| PubChem Substance ID | 135726994 |
| Merck Index (14) | 4478 |
| MDL Number | MFCD00056625 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.5 area% |
| Purity(Neutralization titration) | min. 98.5 % |
| Melting point | 172.0 to 176.0 °C |
Properties (reference)
| Melting Point | 174 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Ethanol, Methanol |
GHS
Related Laws:
| RTECS# | YS4725200 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Glibenclamide: A Sulfonylurea ATP-Dependent K+ Channel Antagonist
Glibenclamide belongs to sulfonylurea antidiabetics which increase the release of insulin from pancreatic B-cells. Sulfonylurea antidiabetics inhibit ATP-gated K+ channels and thereby cause depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. Recently, a combination agent with metformin [M2009] is also used for the treatment of Type 2 diabetes. (The product is for research purpose only.)
References
- Glyburide: a second-generation sulfonylurea hypoglycemic agent. History, chemistry, metabolism, pharmacokinetics, clinical use and adverse effects (a review)
- Sulfonylurea receptor 2B and Kir6.1 form a sulfonylurea-sensitive but ATP-insensitive K+ channel
- Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide
- Sulfonylurea stimulation of insulin secretion (a review)
- Glyburide/metformin tablets: a new therapeutic option for the management of Type 2 diabetes (a review)
- The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide, or glimperide in plasma
- Simultaneous estimation of six anti-diabetic drugs-glibenclamide, gliclazide, glipizide, pioglitazone, repaglinide and rosiglitazone: development of a novel HPLC method for use in the analysis of pharmaceutical formulations and its application to human plasma assay
- Liquid chromatography tandem mass spectrometry method for simultaneous determination of antidiabetic drugs metformin and glyburide in human plasma
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