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CAS RN: 129618-40-2 | Product Number: N0922

Nevirapine


Purity: >98.0%(GC)
Synonyms:
  • 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
Documents:
200MG
¥780.00
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Product Number N0922
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__1__5H__1__4N__4O = 266.3  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 129618-40-2
Reaxys Registry Number 4757598
PubChem Substance ID 160871291
Merck Index (14) 6490
MDL Number

MFCD00866928

Specifications
Appearance White to Light yellow powder to crystal
Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 97.0 %
Melting point 244.0 to 248.0 °C
Properties (reference)
Melting Point 246 °C
Solubility in water Insoluble
Degree of solubility in water < 0.1 g/l  
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
RTECS# JM5562500
Transport Information:
Customs Control Conditions (Q)
Application
Nevirapine: A Non-Nucleoside Reverse Transcriptase Inhibitor

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that active against HIV-1. Nevirapine selectively inhibits HIV-1 but not HIV-2 and any of the human DNA polymerases. Nucleoside reverse transcriptases (NRTIs) compete with natural nucleic acid triphosphates for inhibitory action, whereas nevirapine does not compete with the triphosphates. Nevirapine bind to an active site of the reverse transcriptase molecule of HIV-1, and inhibits the transcriptase activity. Therefore, nevirapine is also active against NRTI (e.g. azidothymidine) resistant HIV-1. (The product is for research purpose only.)

References


PubMed Literature


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