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CAS RN: 85416-73-5 | Product Number: R0183
(S)-(+)-Rolipram
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Purity: >98.0%(HPLC)
Synonyms:
- (S)-(+)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 10MG |
¥140.00
|
1 | Contact Us | 27 |
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| Product Number | R0183 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__1NO__3 = 275.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 85416-73-5 |
| Reaxys Registry Number | 6687797 |
| PubChem Substance ID | 354333407 |
| MDL Number | MFCD03093861 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Optical purity(LC) | min. 97.0 ee% |
| Elemental analysis(Nitrogen) | 4.50 to 5.50 % |
| Melting point | 132.0 to 136.0 °C |
| Specific rotation [a]20/D | +29.0 to +34.0 deg(C=0.5, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 134 °C |
| Specific Rotation | 32° (C=0.5,MeOH) |
GHS
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Application
(S)-(+)-Rolipram: The Less Active Enantiomer of Rolipram, PDE4 Inhibitor
(S)-(+)-Rolipram is the less active enantiomer of the PDE4 inhibitor rolipram [R0110]. The active enantiomer (R)-(-)-rolipram [R0182] also available. It has been reported that (S)-(-)-rolipram is approximately 3 times less potent than (R)-(+)-rolipram against PDE4. In 2015, Kobayashi et al. have been reported a new multistep continuous-flow synthesis of (R)- and (S)-rolipram using only columns packed with heterogeneous catalysts. (The product is for research purpose only.)
References
- Stereospecificity of rolipram actions on eosinophil cyclic AMP-specific phosphodiesterase
- Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret
- Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts
- Flow “Fine” Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods
PubMed Literature
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