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CAS RN: 506-32-1 | Product Number: A0781

Arachidonic Acid


Purity: >98.0%(GC)(T)
Synonyms:
  • 5,8,11,14-Eicosatetraenoic Acid
  • 5,8,11,14-Icosatetraenoic Acid
Documents:
100MG
€54.00
2   ≥20 
500MG
€162.00
1   ≥20 

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*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number A0781
Purity / Analysis Method >98.0%(GC)(T)
Molecular Formula / Molecular Weight C__2__0H__3__2O__2 = 304.47  
Physical State (20 deg.C) Liquid
Storage Temperature <0°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Air Sensitive,Heat Sensitive
Packaging and Container 100MG-Ampule (View image),  500MG-Ampule (View image)
CAS RN 506-32-1
Reaxys Registry Number 1913991
PubChem Substance ID 87562313
SDBS (AIST Spectral DB) 7566
Merck Index (14) 765
MDL Number

MFCD00004417

Specifications
Appearance Colorless to Light yellow to Light orange clear liquid
Purity(GC) min. 98.0 %
Purity(Neutralization titration) min. 98.0 %
Properties (reference)
Specific Gravity (20/20) 0.92
Refractive Index 1.49
Solubility in water Insoluble
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
EC Number 208-033-4
RTECS# CE6675000
Transport Information:
HS Number 2916199590
Application
Reagent for platelet aggregation model
References

Arachidonic acid induced mortality in animals - an appropriate model for the evaluation of antithrombotic drugs?

F. Seuter, W. D. Busse, Agents Actions Suppl. 1979, 4, 175.

Influence of aspirin, molsidomine, trapidil, and some trapidil derivatives on arachidonic acid induced reversible thrombocyte aggregation in the rabbit

U. Zehl, H. J. Mest, W. Förster, Biomed. Biochim. Acta. 1984, 43, 381.


Application
Reagent for acute inflammatory (ear edema) model
References

The mouse ear inflammatory response to topical arachidonic acid

J. M. Young, D. A. Spires, C. J. Bedord, B. Wagner, S. J. Ballaron, L. M. De Young, J. Invest. Dermatol. 1984, 82, 367.

Effect of anti-inflammatory compounds on edema formation and myeloperoxidase activity in the arachidonic acid-induced ear model in the mouse

B. Kotyuk, A. Raychaudhuri, G. DiPasquale, Agents Actions 1993, 39, C46.

Inhibition of arachidonic acid-induced ear oedema as a model for assessing topical anti-inflammatory compounds

A. Crummey, G. P. Harper, E. A. Boyle, F. R. Mangan, Agents Actions 1987, 20, 69.

ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model

T. Horizoe, N. Nagakura, K. Chiba, H. Shirota, M. Shinoda, N. Kobayashi, N. Numata, Y. Okamoto, S. Kobayashi, Inflamm. Res. 1998, 47, 375.


Application
Reagents for cerebral infarction model
References

Arachidonate-induced cerebrovascular occlusion in the rat. The role of platelets and aspirin in stroke

T. W. Furlow Jr., N. H. Bass, Neurology 1976, 26, 297.

The sodium arachidonate-induced cerebral infarct in the rat: a model for the study of drugs

J. Cahn, M. G. Borzeix, J. Cereb. Blood Flow Metab. 1982, 2 Suppl 1, 74.


Application
Reagent for conjunctivitis model
References

Effects of bromfenac sodium, non-steroidal anti-inflammatory drug, on acute ocular inflammation

T. Ogawa, T. Sakaue, T. Terai, O. Fukiage, Nihon Ganka Gakkai Zasshi, 1995, 99, 406.

Topical arachidonic acid: a model for screening anti-inflammatory agents

M. B. Abelson, S. I. Butrus, G. H. Kliman, D. L. Larson, E. J. Corey, L. M. Smith, J. Ocul. Pharmacol. 1987, 3, 63.

Effects of sodium naproxen eye drops on rabbit ocular inflammation induced by sodium arachidonate

S. Spampinato, A. Marino, C. Bucolo, M. Canossa, T. Bachetti, S. Mangiafico, J. Ocul. Pharmacol. 1991, 7, 125.

Differential inflammatory effects of arachidonic acid on rabbit conjunctiva and iris: a possible role of lipoxygenase in the conjunctival response

P. Bhattacherjee, P. S. Kulkarni, K. E. Eakins, Adv. Prostaglandin Thromboxane Res. 1980, 8, 1727.


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