CAS RN: 3543-75-7 | Product Number: B4033
Bendamustine Hydrochloride Hydrate
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|Purity / Analysis Method||>98.0%(T)(HPLC)|
|Molecular Formula / Molecular Weight||C__1__6H__2__1Cl__2N__3O__2·HCl·xH__2O = 394.72|
|Physical State (20 deg.C)||Solid|
|Related CAS RN||16506-27-7|
|Reaxys Registry Number||6031568|
|PubChem Substance ID||172089039|
|Merck Index (14)||1034|
|Appearance||White to Almost white powder to crystal|
|Purity(HPLC)||min. 98.0 area%|
|Purity(Neutralization titration)||min. 98.0 %(calcd.on anh.substance)|
|Melting point||165.0 to 169.0 °C|
|Water||3.0 to 6.0 %|
|Melting Point||167 °C|
|Hazard Statements||H301 : Toxic if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
H371 : May cause damage to organs.
H341 : Suspected of causing genetic defects.
H351 : Suspected of causing cancer.
|Precautionary Statements||P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
Bendamustine hydrochloride, an antitumor alkylating agent, was first synthesized in 1963 in the German Democratic Republic. It is a unique cytotoxic chemotherapeutic agent with structural similarities to alkylating agents and antimetabolites containing a purine-like benzimidazole ring, but which is non-cross-resistant with alkylating agents. Bendamustine form covalent bonds with electron-rich nucleophilic moieties, resulting in interstrand DNA crosslinks. This covalent linkage can lead to cell death via several pathways. Recently, bendamustine is re-evaluated as an antitumor agent, and widely used for the treatment of indolent non-Hodgkin's lymphoma (NHL) and mantle cell lymphoma (MCL). (The product is for research purpose only.)
Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines
Bendamustine (Treanda) Displays a Distinct Pattern of Cytotoxicity and Unique Mechanistic Features Compared with
Bendamustine Is Effective in p53-Deficient B-Cell Neoplasms and Requires Oxidative Stress and Caspase-Independent Signaling
Bendamustine: rebirth of an old drug (a review)
Stability-Indicating LC Method for the Estimation of Bendamustine Hydrochloride and its Related Impurities
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