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CAS RN: 107868-30-4 | Product Number: E0941

Exemestane


Purity: >98.0%(GC)
Synonyms:
  • 6-Methyleneandrosta-1,4-diene-3,17-dione
Documents:
200MG
€ 31,00
1   5  
1G
€ 109,00
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Product Number E0941
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__2__0H__2__4O__2 = 296.41  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 107868-30-4
Reaxys Registry Number 6609645
PubChem Substance ID 172089054
Merck Index (14) 3913
MDL Number

MFCD00866994

Specifications
Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Melting point 192.0 to 196.0 °C
Specific rotation [a]20/D +280 to +300 deg(C=1、MeOH)
Properties (reference)
Melting Point 194 °C
Specific Rotation 290° (C=1,MeOH)
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H360 : May damage fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# BV7988700
Transport Information:
HS Number 2937290000
Application
Exemestane: A Potent and Selective Aromatase Inhibitor

Exemestane, anastrozole [A2370] and letrozole [L0248] are third generation, and potent and selective aromatase inhibitors. Aromatase is responsible enzyme for the aromatization of androgens ([A0845] and [T0027]) into estrogens ([E0026] and [E0025]) respectively in the periphery. Exemestane, anastrozole and letrozole inhibit aromatase and estrogen synthesis, resulting in suppressing tumor growth. Exemestane alone or a combination agent with tamoxifen citrate [T2510] is used for the treatment for postmenopausal women with breast cancer. (The product is for research purpose only.)

References


PubMed Literature


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