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CAS RN: 75607-67-9 | Product Number: F0913

Fludarabine Monophosphate


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 2-Fluoroadenine 9-β-D-Arabinofuranoside 5'-Monophosphate
  • 9-(β-D-Arabinofuranosyl)-2-fluoroadenine 5'-Monophosphate
  • 2-F-ara-AMP
Documents:
25MG
€34.00
1   12  
100MG
€102.00
1   18  

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Product Number F0913
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__3FN__5O__7P = 365.21  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic
CAS RN 75607-67-9
Reaxys Registry Number 8167686
PubChem Substance ID 253660324
Merck Index (14) 4126
MDL Number

MFCD00866418

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Specific rotation [a]20/D +11.0 to +13.0 deg(C=0.5, H2O)
Properties (reference)
Melting Point 203 °C(dec.)
Specific Rotation 12° (C=0.5,H2O)
Solubility in water Practically insoluble
Degree of solubility in water 8.9 g/l   20 °C
Solubility (very soluble in) Dimethylformamide
Solubility (insoluble in) Ether,Ethanol
GHS
Pictogram Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
H362 : May cause harm to breast-fed children.
H373 : May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements P263 : Avoid contact during pregnancy and while nursing.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
Related Laws: / Compliance with laws, Regulations
RTECS# UO7440900
Transport Information:
HS Number 2934999090
Application
Fludarabine phosphate (2-F-ara-AMP): An Inhibitor of DNA Synthesis

Fludarabine phosphate (2-F-ara-AMP) is an adenine nucleoside analog that is converted first to 9-β-D-arabinofuranosyl-2-fluoradenine (2-F-ara-A) and then into the active metabolite 2-F-ara-A triphosphate (F-ara-ATP). The triphosphate inhibits the synthesis of primer RNA and DNA by DNA polymerase primase complex, and also induces cell death through apoptosis. Fludarabine phosphate shows activity against chronic lymphocytic leukemia (CLL) and indolent lymphoma. (The product is for research purpose only.)

References


PubMed Literature


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