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CAS RN: 1104-22-9 | Product Number: M2755

Meclizine Dihydrochloride

Purity: >98.0%(HPLC)
  • 1-(4-Chlorobenzhydryl)-4-(3-methylbenzyl)piperazine Dihydrochloride
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Product Number M2755
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__5H__2__7ClN__2·2HCl = 463.87  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 1104-22-9
Related CAS RN 569-65-3
Reaxys Registry Number 3798111
PubChem Substance ID 253661196
MDL Number


Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 95.0 %
Melting point 210.0 to 214.0 °C
Properties (reference)
Melting Point 212 °C
Solubility in water Insoluble
Solubility (very soluble in) Chloroform
Solubility (slightly sol. in) Alcohol
Solubility (insoluble in) Ether
Pictogram Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
Related Laws:
EC Number 214-164-8
RTECS# TL2005000
Transport Information:
HS Number 2933599590

Meclizine hydrochloride, a piperazine class of histamine H1 receptor antagonists, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine also has anticholinergic activity probably because of its dopamine receptors antagonist activities. In addition, meclizine has been reported to be an inverse agonist of constitutive androstane receptor (CAR). Based on studies conducted on rats, meclizine undergoes extensive hepatic metabolism to an inactive metabolite, norchlorcyclizine or 1-(4-chlorobenzhydryl)piperazine [C1611]. Meclizine hydrochloride is a poorly water-soluble agent having a very slow-onset of action. Therefore, the water solubility enhancement of meclizine hydrochloride has been studied.


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