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CAS RN: 70458-96-7 | Product Number: N0817

Norfloxacin


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid
Documents:
5G
€62.00
2   ≥20 
25G
€142.00
3   8  

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Product Number N0817
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__6H__1__8FN__3O__3 = 319.34  
Physical State (20 deg.C) Solid
CAS RN 70458-96-7
Reaxys Registry Number 567897
PubChem Substance ID 125307523
SDBS (AIST Spectral DB) 52829
Merck Index (14) 6700
MDL Number

MFCD00079532

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Properties (reference)
Melting Point 221 °C
GHS
Related Laws:
EC Number 274-614-4
RTECS# VB2005000
Transport Information:
HS Number 2933599590
Application
初のフルオロキノロン系合成抗菌剤,ノルフロキサシン

Norfloxacin is the first fluoroquinolone antibacterial reagent which is synthesized from [C2897] with piperazine. Its structure is related to nalidixic acid [N0490] but its potency has been increased by a fluorine atom and by a piperazine moeity. Thereby, norfloxacin has a broad spectrum of activity against both Gram-positive bacteria and Gram-negative bacteria. Norfloxacin and the other fluoroquinolones inhibit bacterial DNA synthesis by inhibiting the enzyme gyrase which catalyzes the operations of the DNA double strand such as opening, under winding, and closing. Fluoroquinolones appear to prevent specifically the resealing of opened DNA strands and thereby act bactericidally.

References


PubMed Literature


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