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CAS RN: 59-33-6 | Product Number: P2369

Pyrilamine Maleate

Purity: >98.0%(T)(HPLC)
  • Mepyramine Maleate
  • N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine Maleate
4   ≥20 
3   17  

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Product Number P2369
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__7H__2__3N__3O·C__4H__4O__4 = 401.46  
Physical State (20 deg.C) Solid
Condition to Avoid Light Sensitive
CAS RN 59-33-6
Related CAS RN 91-84-9
Reaxys Registry Number 3836479
PubChem Substance ID 354333684
Merck Index (14) 7984
MDL Number


Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 %(total of Ion-Pair)
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 100.0 to 104.0 °C
Properties (reference)
Melting Point 102 °C
Maximum Absorption Wavelength 310(EtOH) nm
Solubility in water Soluble
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
EC Number 200-422-7
RTECS# UT1225000
Transport Information:
HS Number 2933399990
Pyrilamine Maleate: A First Generation Histamine H1 Receptor Antagonist

Pyrilamine maleate, also known as pyrilamine maleate, is a first generation histamine H1 receptor antagonist. Pyrilamine binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Pyrilamine permeates the blood-brain barrier causing drowsiness. Pyrilamine also has anticholinergic properties. For reference, we also have related first generation histamine H1 receptor antagonists, such as pheniramine maleate [P2271], chlorpheniramine maleate [C0873] and bromopheniramine maleate [B5167]. (The product is for research purpose only.)


PubMed Literature

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