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Monomers, Macromonomers [Biomaterials/Biocompatible Materials Research Reagents]

Monomers for Biomaterials/Biocompatible Materials Research

We present in this category the monomers used for biomaterials research classified according to their chemical structures such as acrylic monomers, lactone monomers, dithiol monomers, and diisocyanate monomers.

Among them acrylic monomers contain largest number of products and are often utilized for biomaterials or biocompatible materials research, using conventional radical polymerization or controlled radical polymerization. In addition to the common monomers for biomaterials research including 2-hydroxyethyl methacrylate (HEMA) [M0085]1) and N-isopropylacrylamide (NIPAAm) [I0401]2), TCI has zwitterionic monomers or monomers with reactive functional groups useful for conjugation with proteins or peptides present in our catalog.

M0085, I0401

Zwitterionic monomers contain both cationic and anionic groups in the same molecule. Common zwitterionic monomer structures include phosphobetaines, sulfobetaines, and carboxybetaines.3,4) One of the phosphobetaine zwitterionic monomers, 2-(methacryloyloxy)ethyl 2-(trimethylammonio)ethyl phosphate (MPC) [M2005]5) is the most studied zwitterionic monomer and has been applied to toiletries or soft contact lenses.4) TCI offers 3-[[2-(methacryloyloxy)ethyl]dimethylammonio]propane-1-sulfonate (SPE) [M1971]6) as a sulfobetaine monomer,3-[[2-(methacryloyloxy)ethyl]dimethylammonio]propionate [M2359]7) and 3-[(3-acrylamidopropyl)dimethylammonio]propanoate [A3279]7) as carboxybetaine monomers.

M0085, I0401

Zwitterionic polymers synthesized from its zwitterionic monomers are expected to be applied to surface coating materials in medical devices including stents, catheters, and membranes for dialysis.4,8,9,10,11) Research towards drug delivery system (DDS) have been increasing lately; e.g. application as nanomicellar drug carriers,12) as coating materials for nanoparticles with prolonged blood circulation,13) and as hydrogels providing sustained release of the therapeutic materials.14) Application for assays or diagnosis are also expected, and noise reduction of a glucose sensor by coating electrodes by zwitterionic polymers was also reported.15) In addition, cell culture mediums are another promising application of zwitterionic monomers. For example, expansion of human hematopoietic stem cells with reduced differentiation on a zwitterionic hydrogel was reported.16)

As monomers are helpful for the conjugation of polymers with proteins or peptides, TCI provides N-succinimidyl acrylate [S0814] and N-succinimidyl methacrylate [S0812] having NHS ester moiety which react with primary amines, and pentafluorophenyl acrylate [P2179] and pentafluorophenyl methacrylate [P2289] having pentafluorophenyl ester group, etc.

M0085, I0401



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