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CAS RN: 62571-86-2 | Product Number: C1580
Captopril
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (S)-(-)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
- (S)-(-)-1-(3-Mercapto-2-methylpropionyl)-L-proline
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
$68.00
|
38 | 0 | Contact Us | |
| 25G |
$229.00
|
19 | 0 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | C1580 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__5NO__3S = 217.28 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 62571-86-2 |
| Reaxys Registry Number | 477887 |
| PubChem Substance ID | 87566575 |
| SDBS (AIST Spectral DB) | 16831 |
| Merck Index (14) | 1774 |
| MDL Number | MFCD00168073 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity( Potassium iodate Method) | min. 98.0 % |
| Melting point | 105.0 to 110.0 °C |
| Specific rotation [a]20/D | -125 to -134 deg(C=1, EtOH) |
| Solubility in Methanol | almost transparency |
Properties (reference)
| Melting Point | 106 °C |
| Specific Rotation | -127.5° (C=1,EtOH) |
GHS
Related Laws:
| RTECS# | UY0550000 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Captopril: An Orally Active ACE Inhibitor
Captopril (SQ 14225) is an orally active angiotensin-converting enzyme inhibitor often called ACE inhibitor. Angiotensin I is converted by angiotensin-converting enzyme (ACE) to angiotensin II, a potent endogenous vasoconstrictor substance. ACE inhibitors occupy the active center of ACE so that cleavage of angiotensin I is inhibited competitively. The elevation of blood pressure is then attenuated or abolished by diminished production of angiotensin II. (The product is for research purpose only.)
References
- SQ 14,225 (D-3-mercapto-2-methylpropanoyl-l-proline), a novel orally active inhibitor of angiotensin I-converting enzyme
- Antihypertensive activity in rats for SQ 14,225, an orally active inhibitor of angiotensin I-converting enzyme
- Captopril: a preliminary review of its pharmacological properties and therapeutic efficacy
- Controlled release of captopril by regulating the pore size and morphology of ordered mesoporous silica
- Captopril (a review on the history, synthesis, properties, methods of detection, and pharmacology)
- Automated determination of captopril by flow and sequential injection analysis: a review
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