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CAS RN: 73963-72-1 | Product Number: C2587
Cilostazol
×
Purity: >98.0%(HPLC)
Synonyms:
- 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
$45.00
|
9 | ≥40 | Contact Us | |
| 5G |
$154.00
|
10 | ≥40 | Contact Us |
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| Product Number | C2587 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__7N__5O__2 = 369.47 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 73963-72-1 |
| Reaxys Registry Number | 3632107 |
| PubChem Substance ID | 160870980 |
| Merck Index (14) | 2277 |
| MDL Number | MFCD00866780 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 158.0 to 162.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 160 °C |
| Maximum Absorption Wavelength | 257 nm (MeOH) |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Methanol |
| Solubility (insoluble in) | Ether |
GHS
Related Laws:
| RTECS# | VC8277500 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Cilostazol: A Selective Inhibitor of Cyclic Nucleotide Phosphodiesterase 3 (PDE3)
Cilostazol is originally developed as a selective inhibitor of cyclic nucleotide phosphodiesterase 3 (PDE3). PDE3 inhibition in platelets and vascular smooth muscle cells is expected to provide an antiplatelet effect and vasodilatation, with therapeutic focus on cAMP. Recently, it has been reported that cilostazol is effective in vascular dementia associated with a cerebral ischemia. (The product is for research purpose only.)
References
- Effect of cilostazol on platelet aggregation and experimental thrombosis
- Y. Kimura, T. Tani, T. Kanbe, K. Watanabe, Arzneim.-Forsch. 1985, 35, 1144.
- Effect of cilostazol, a cyclic AMP phosphodiesterase inhibitor, on the proliferation of rat aortic smooth muscle cells in culture
- Cilostazol as a unique antithrombotic agent
- Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain
- Cilostazol prevents amyloid β peptide25-35-induced memory impairment and oxidative stress in mice
Application
Dissolution Studies
Reference
- Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs
PubMed Literature
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