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CAS RN: 114977-28-5 | Product Number: D4102
Docetaxel
×
Purity: >98.0%(HPLC)
Synonyms:
- N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$111.00
|
9 | 3 | It can be shipped in about 2 weeks after ordering | |
| 1G |
$524.00
|
6 | 1 | It can be shipped in about 2 weeks after ordering |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | D4102 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__3H__5__3NO__1__4 = 807.89 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 114977-28-5 |
| Reaxys Registry Number | 4290183 |
| PubChem Substance ID | 160871242 |
| Merck Index (14) | 3397 |
| MDL Number | MFCD00800737 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -42.0 to -45.0 deg(C=1、EtOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 188 °C(dec.) |
| Specific Rotation | -43° (C=1,EtOH) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Methanol, dichloromethane, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | DA4172750 |
Transport Information:
| H.S.code* | 2932.99-000 |
Application
Docetaxel: A Microtubule Stabilizer and a Depolymerization Inhibitor
Docetaxel (taxotere, RP 56976) is an active semisynthetic analog of paclitaxel (taxol) [P1632] which is isolated from the bark of the Pacific yew, Taxus brevifolia. Docetaxel promotes tubulin assembly in microtubules and inhibits their depolymerization, leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. Docetaxel has solubility in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), but very poor solubility in water. Therefore, enhanced the solubility of docetaxel in water, some controlled-release drug delivery systems have been studied. For your reference, [B4127] is a synthetic Intermediate of the side chains of docetaxel and paclitaxel. (The product is for research purpose only.)
References
- Studies with RP 56976 (taxotere): a semisynthetic analog of taxol
- Experimental antitumor activity of Taxotere (RP 56976, NSC 628503), a taxol analog
- Taxol and taxotere: discovery, chemistry, and structure-activity relationships (a review)
- Docetaxel (a review of its activity, tolerability, and pharmacokinetics in preclinical and clinical experience)
- Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
- Sensitive liquid chromatography-mass spectrometry assay for quantitation of Docetaxel and Paclitaxel in human plasma
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