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CAS RN: 54573-75-0 | Product Number: D5526

Doxercalciferol


Purity: >98.0%(HPLC)
Synonyms:
  • (5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3-diol
Documents:
5MG
$99.00
6   3  
25MG
$357.00
10   23  

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number D5526
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__8H__4__4O__2 = 412.66 
Physical State (20 deg.C) Solid
Storage Temperature Frozen (-20°C)
Condition to Avoid Heat Sensitive
CAS RN 54573-75-0
Reaxys Registry Number 4716774
PubChem Substance ID 468591388
Merck Index (14) 3436
MDL Number

MFCD00871065

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Specific rotation [a]20/D +46.0 to +50.0 deg(C=0.5,EtOH)
Elemental analysis(Carbon) 79.90 to 83.10 %
Properties (reference)
Melting Point 140 °C
Maximum Absorption Wavelength 265(EtOH) nm
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 : Fatal if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# VS2950000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group I
H.S.code* 2936.29-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Doxercalciferol: A Prodrug of 1α,25-Dihydroxyvitamin D2, an Active Form of Vitamin D2

Doxercalciferol (other name: 1α-hydroxyvitamin D2), a synthetic vitamin D2 analog, was first synthesized from ergosterol [E0018].1) It is a prodrug requiring hepatic metabolism to the active metabolite 1α,25-dihydroxyvitamin D2 (1α, 25-(OH)2D2), a biologically active form of vitamin D2.2) The active vitamin D2 binds the vitamin D receptor (VDR) to result in the selective activation of vitamin D responsive pathway. It has been reported that doxercalciferol reduces parathyroid hormone (PTH) levels by inhibiting PTH synthesis and secretion.3) In clinical, doxercalciferol is used for the treatment of secondary hyperparathyroidism (2HPT) and metabolic bone disease.3,4) (The product is for research purpose only.)

References


Documents (Note: Some products will not have analytical charts available.)
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