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CAS RN: 85118-33-8 | Product Number: G0405
Gaboxadol Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
$89.00
|
31 | 17 | Contact Us |
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| Product Number | G0405 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__6H__8N__2O__2·HCl = 176.60 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 85118-33-8 |
| Related CAS RN
|
64603-91-4 |
| Reaxys Registry Number | 6534899 |
| PubChem Substance ID | 253659629 |
| Merck Index (14) | 4321 |
| MDL Number | MFCD00055180 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 15.40 to 16.30 % |
Properties (reference)
| Melting Point | 236 °C |
GHS
Related Laws:
| RTECS# | NY3398000 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Gaboxadol Hydrochloride: A γ-Aminobutyric Acid Subtype A (GABAA) Receptor Agonist
Gaboxadol hydrochloride, also known as THIP, is a direct-acting γ-aminobutyric acid subtype A (GABAA) receptor agonist. GABAA receptor is widely considered to be an important target for most clinically effective sedative-hypnotic compounds. However, the clinical development program for gaboxadol was discontinued in 2007. (The product is for research purpose only.)
References
- Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors
- GABAA receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol
- An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons
- Gaboxadol - a new awakening in sleep(a review)
- GABAA agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic(a review)
- Development and validation of a selective and sensitive bioanalytical procedure for the quantitative determination of gaboxadol in human plasma employing mixed mode solid phase extraction and hydrophilic interaction liquid chromatography with tandem mass spectroscopic detection
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