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CAS RN: | Product Number: M3544
N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water) [for transcription] [for Molecular Biology]
![Thumbnail of N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water) [for transcription] [for Molecular Biology]](/medias/Tci-98-M3544.jpg?context=bWFzdGVyfHJvb3R8MjgyMXxpbWFnZS9qcGVnfGFESTFMMmc0WXk4NU16a3lNRFF6TURNeU5qQTJMMVJqYVMwNU9GOU5NelUwTkM1cWNHY3xlZWUxNTkxNmYwOTUzZThhNDNlMTI0ZGJlN2Q3YTE5YmRmYTQ4YmYxYWViOWRhYjJkOTk5NzhhMmQ2ODMzOTJi "N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water) [for transcription] [for Molecular Biology]")
![Chemical Structure of N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water) [for transcription] [for Molecular Biology]](/medias/Tci-440-M3544.jpg?context=bWFzdGVyfHJvb3R8MjA4NDh8aW1hZ2UvanBlZ3xhR013TDJnME1TODVNemt5TURReU9UazVPRE00TDFSamFTMDBOREJmVFRNMU5EUXVhbkJufDNlY2U2MGUwYzg2MWQ5YTY5Y2Q3MGNjYTQ3ZmUwMDY1N2RiZjMzOGIyNTY0NzkyNDk0ODMzNWJmZGQ1NmNlMmE "N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water) [for transcription] [for Molecular Biology]")
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![N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water) [for transcription] [for Molecular Biology]](/_ui/responsive/theme-tci/images/missing_product_zoom.webp "N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water) [for transcription] [for Molecular Biology]")
Purity:
Synonyms:
- [(2R,3S,4R,5S)-3,4-Dihydroxy-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-2-yl]methyl Tetrahydrogen Triphosphate Sodium Salt (ca. 100mM in Water)
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 0.01ML |
$64.00
|
0 | ≥40 | Contact Us | |
| 0.25ML |
$282.00
|
11 | 0 | Contact Us |
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* The storage conditions are subject to change without notice.
Supplemental Product Information:
Due to the limited filling volume, some of the product may stick to the inner walls of the bottle.
| Product Number | M3544 |
| Molecular Formula / Molecular Weight | C__1__0H__1__7N__2O__1__5P__3·xNa |
| Physical State (20 deg.C) | Liquid |
Storage Temperature 
|
Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Related CAS RN
|
1428903-59-6&1931922-77-8 |
Specifications
| Appearance | Colorless to Almost colorlessclear liquid |
| Purity(HPLC) | min. 95.0 area% |
| Concentration(HNMR) | 0.100 to 0.110 mol/L |
| DNase detection test | to pass test |
| RNase detection test | to pass test |
| Transcription test | to pass test |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water): A Modified Nucleotide for the Development of Next-Generation Vaccines
In recent years, numerous studies have demonstrated that mRNA has outstanding abilities to elicit potent immune responses, making it a viable new platform for the development of next-generation vaccines.1) There are further reports on the incorporation of modified nucleobases into mRNA which provide advantages for the generation of potent and long-lived antibody responses. This product is the 5'-triphosphate sodium salt of 1-methylpseudouridine (m1Ψ) [M3387] which enhances immune evasion, protein production, and consequently improves vaccine efficacy.2,3) We confirm that this product (m1Ψ-triphosphate) is used for the incorporation of it into mRNA by RNA polymerase, as well as transcription.
References
- 1) mRNA vaccine for cancer immunotherapy (a review)
- 2) Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines (a review)
- 3) N1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells
PubMed Literature
Please visit the Pubchem page at this link.
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[Featured Products] RNA Base-modified Nucleoside Triphosphate for mRNA Medicine Development[Featured Products] Base-modified Ribonucleoside Triphosphates for mRNA Drug Discovery
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