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CAS RN: 84-02-6 | Product Number: P2368
Prochlorperazine Dimaleate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine Dimaleate
Product Documents:
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| 5G |
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| Product Number | P2368 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__4ClN__3S·2C__4H__4O__4 = 606.09 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 84-02-6 |
| Related CAS RN | 58-38-8 |
| Reaxys Registry Number | 3861788 |
| PubChem Substance ID | 354335064 |
| Merck Index (14) | 7761 |
| MDL Number | MFCD00069330 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 194 °C(dec.) |
| Maximum Absorption Wavelength | 313 nm (MeOH) |
| Solubility in water | Insoluble |
| Solubility (insoluble in) | Diethyl ether, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | SO3150000 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Prochlorperazine Dimaleate: A Dopamine Receptor Antagonist with Antipsychotic Activity
Prochlorperazine dimaleate is a phenothiazine antipsychotic agent with a piperazine moiety in the side chain. Prochlorperazine possesses strong antiemetic and antipsychotic activity with less sedative action than chlorpromazine [C2481]. The precise mechanism of actions is not fully understood. However, prochlorperazine works as a dopamine and α-adrenergic receptors antagonist, and the functions may be related to the therapeutic effect in psychotic conditions. In addition, there is good evidence to suggest that, in common with other phenothiazine agents, prochlorperazine has antibacterial activity. (The product is for research purpose only.)
References
- Prochlorperazine ― A Review of the Literature since 1956
- Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine
- Simultaneous quantitation of plasma doxorubicin and prochlorperazine content by high-performance liquid chromatography
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