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CAS RN: 103628-48-4 | Product Number: S0851
Sumatriptan Succinate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl-N-methylmethanesulfonamide Succinate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$112.00
|
30 | 0 | It can be shipped in about 2 weeks after ordering | |
| 1G |
$492.00
|
0 | 14 | It can be shipped in about 2 weeks after ordering |
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| Product Number | S0851 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__2__1N__3O__2S·C__4H__6O__4 = 413.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 103628-48-4 |
| Related CAS RN
|
103628-46-2 |
| Reaxys Registry Number | 5371868 |
| PubChem Substance ID | 160871034 |
| Merck Index (14) | 8997 |
| MDL Number | MFCD00902856 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 165.0 to 169.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 167 °C |
| Solubility in water | Soluble |
| Degree of solubility in water | 170 g/l 24 °C |
| Solubility (insoluble in) | Ethanol, Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H318 : Causes serious eye damage. |
| Precautionary Statements | P280 : Wear eye protection/ face protection. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
| RTECS# | EJ9940000 |
Transport Information:
| H.S.code* | 2935.90-000 |
Application
Sumatriptan Succinate: A Selective 5-HT1B/1D Receptor Agonist
Sumatriptan succinate is a selective 5-HT1B/1D receptor agonist, belongs to triptans. Sumatriptan binds with high affinity to 5-HT1 receptor subtypes (5-HT1B, 5-HT1D), but has only a week affinity for a serotonergic receptor subtype (5-HT1A) and has no significant affinity for serotonergic receptor subtypes (5-HT1c, 5-HT2, 5-HT3) or for adrenergic (α1, α2, β), dopamine (D1, D2), muscarinic, or benzodiazepine receptors. Animal studies shows that sumatriptan presumably exerts its therapeutic effects in the treatment of migraine headache through agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system. In addition, the transdermal iontophoretic patch of sumatriptan succinate is developed. (The product is for research purpose only.)
References
- Comparative Neuropharmacology of Dihydroergotamine and Sumatriptan (GR 43175)
- Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine(a review)
- Triptans in migraine: A comparative review of pharmacology, pharmacokinetics and efficacy
- Effect of chemical enhancers on the in vitro percutaneous absorption of sumatriptan succinate
- In vitro and in vivo evaluation of the transdermal iontophoretic delivery of sumatriptan succinate
- Review of Analytical Methods for Identification and Determination of Triptans (a review)
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