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CAS RN: 64-75-5 | Product Number: T2525
Tetracycline Hydrochloride
×
Purity: >98.0%(T)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25G |
$44.00
|
0 | 0 | It can be shipped in about 2 weeks after ordering | |
| 100G |
$137.00
|
5 | 0 | It can be shipped in about 2 weeks after ordering |
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| Product Number | T2525 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__2__2H__2__4N__2O__8·HCl = 480.90 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 64-75-5 |
| Related CAS RN
|
60-54-8 |
| Reaxys Registry Number | 3844873 |
| PubChem Substance ID | 87560362 |
| Merck Index (14) | 9196 |
| MDL Number | MFCD00078142 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -240 to -255 deg(C=0.5, 0.1mol/L HCl) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 214 °C(dec.) |
| Specific Rotation | -253° (C=0.5,0.1mol/L HCl) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | QI9100000 |
Transport Information:
| H.S.code* | 2941.30-000 |
Application
Biofilm research
Susceptibility of Actinobacillus actinomycetemcomitans, strain 310a, biofilm to tetracycline has been reported. Adding 0.1 or 1 mg/L of the antibiotic significantly inhibited the biofilm formation in the early phase, but not in the mature phase.1) Although adding 10 mg/L of the antibiotic reduced biofilm development in the early phase, it enhanced biofilm development in the mature phase.
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- Susceptibility of Actinobacillus actinomycetemcomitans to six antibiotics decreases as biofilm matures
- Single-stranded DNA aptamers specific for antibiotics tetracyclines
- Tetracyclines. Antibiotic action, uptake, and resistance mechanisms (a review)
- Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3
- The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit
- Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution (a review)
- Update on acquired tetracycline resistance genes
- In vivo gene regulation using tetracycline-regulatable systems
Application
DNA aptamer research
Reference
Application
Tetracycline: a Broad Spectrum Polyketide Antibiotic and a Selective Reagent Genetically Engineered Cells
Tetracycline is a polyketide antibiotic isolated from Streptomyces genus. Tetracycline has broad activity against Gram-negative bacteria and Gram-positive bacteria, with a few exceptions, such as Pseudomonas aeruginosa and Proteus species. Tetracycline inhibits protein synthesis in susceptible organisms by binding to the A-site on the 50S subunit of a bacterial ribosome. However, tetracycline-resistant bacterial strains appeared soon after its introduction. Tetracycline is used in molecular biology as a selective reagent most commonly to isolate bacteria coupled to a gene coding for tetracycline resistance, which is one of the most frequently used selection markers for obtaining transgenic cells. Recently, tetracycline is used for tetracycline-controlled transcriptional activation systems in cells.
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