Maintenance Notice (11:30 PM October 5 - 4:00 AM October 6, 2024 UTC): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.196 | Product Document Searching Made Easy by 2D Code! | TCI Chemistry News October 2024 | [Product Highlights] A Powerful Acceptor Building Block... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
Maximum quantity allowed is 999
Please select the quantity
SSEAs (Stage-specific embryonic antigens)
Stage-Specific Embryonic Antigens (SSEAs) are glycan antigens known to vary in their expression levels across the stages of embryonic development and cell differentiation.1)
SSEA-1, also called Lewis X Antigen, is expressed on the surface of mouse embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells) and is often used as a mouse pluripotent stem cell marker. SSEA-3 and SSEA-4 are the Globo-series Glycosphingolipids Gb5 and SialylGb5, and are localized on the cell surface of human embryonic cancer cells (EC cells), ES cells, iPS cells and Muse (Multilineage-differentiating Stress Enduring) cells, where they are used as markers. SSEA-4 has also been shown to be overexpressed in many cancers, suggesting a correlation with disease progression.2)
TCI has a wide line-up of mouse monoclonal antibodies, synthetic glycans and glycan conjugates for SSEA-3, SSEA-4, SSEA-1.
Products
*These products are not available in China.
Binding specificity of A3729 and A3742
Subsequently, anti-SSEA-3 antibody (Product No. A3729) or anti-SSEA-4 antibody (Product No. A3742) were added to the wells and allowed to incubate.
Primary antibodies were detected using appropriate secondary antibodies.
A3729 and A3742 show high specificity for each antigen.
Binding specificity of A2578
Anti Lewis X antibody (Product No. A2578) or Anti Sialy Lewis X antibody (Product No. A2849) were then added and allowed to incubate.
Primary antibodies were detected using appropriate secondary antibodies.
A2578 shows high specificity for Lewis X.
Related Products
SSEA-3 (Gb5)-related Products
SSEA-4 (SialylGb5)-related Products
SSEA-1 (Lewis X)-related Products
Globo-series Glycolipids-related Products
Product Brochure
References
- 1) Preimplantation Human Embryos and Embryonic Stem Cells Show Comparable Expression of Stage-Specific Embryonic Antigens
- 2) Expression of stage-specific embryonic antigen-4 (SSEA-4) defines spontaneous loss of epithelial phenotype in human solid tumor cells
