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CAS RN: 82248-59-7 | Product Number: A2357
Atomoxetine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropylamine Hydrochloride
- (R)-Tomoxetine Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
€ 17,00
|
2 | ≥40 |
|
|
| 1G |
€ 94,00
|
2 | 23 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | A2357 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__1NO·HCl = 291.82 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 82248-59-7 |
| Related CAS RN
|
83015-26-3 |
| Reaxys Registry Number | 5318974 |
| PubChem Substance ID | 125307825 |
| Merck Index (14) | 863 |
| MDL Number | MFCD06410992 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 167.0 to 171.0 °C |
| Specific rotation [a]20/D | -41.0 to -44.0 deg(C=1, MeOH) |
Properties (reference)
| Melting Point | 169 °C |
| Specific Rotation | -42° (C=1,MeOH) |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
Transport Information:
| HS Number | 2922190090 |
Application
Atomoxetine Hydrochloride: A Selective Noradrenaline (Norepinephrine) Reuptake Inhibitor
Atomoxetine hydrochloride is a selective noradrenaline (norepinephrine, [A0906]) reuptake inhibitor (NRI). The selective inhibitions of the noradrenaline transporter (NAT) help to reverse the depletion of neurotransmitters at the synapse. There is evidence to suggest that atomoxetine shows beneficial effect for the treatment of attention-deficit/hyperactivity disorder (ADHD), but the precise mechanism is not fully understood. (The product is for research purpose only.)
References
- Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in Attention Deficit/Hyperactivity Disorder
- Atomoxetine: a review of its use in adults with attention deficit hyperactivity disorder
- The neuropharmacology of ADHD drugs in vivo: Insights on efficacy and safety (a review)
- A quality by design approach to impurity method development for atomoxetine hydrochloride (LY139603)
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