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Published TCIMAIL newest issue No.198
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CAS RN: 166518-60-1 | Product Number: A3594
Avasimibe
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Purity: >98.0%(HPLC)
Synonyms:
- 2,6-Diisopropylphenyl [2-(2,4,6-Triisopropylphenyl)acetyl]sulfamate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
€120.00
|
Contact Us | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3594 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__9H__4__3NO__4S = 501.73 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 166518-60-1 |
| Reaxys Registry Number | 7608606 |
| MDL Number | MFCD00934956 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 172.0 to 176.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 174 °C |
GHS
Related Laws:
| RTECS# | CY1482550 |
Transport Information:
| HS Number | 2929909090 |
Application
Avasimibe: An Orally Bioavailable Inhibitor of ACAT (SOAT)
Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT, also known as sterol O-acyltransferase or SOAT) is an intracellular enzyme that catalyzes the formation of cholesteryl esters from cholesterol and fatty acyl-CoA. Avasimibe (Cl-1011) is an orally bioavailable inhibitor of ACAT. Animal studies have shown that ACAT inhibitors, including avasimibe, reduce plasma cholesterol levels by suppressing the absorption of dietary cholesterol.1,2) Recently, many studies have suggested that ACAT-1 (SOAT-1) plays a critical role in cancer initiation and progression and is an attractive target for novel anticancer therapy. The inhibitor avasimibe has been shown to have antitumor activity.3,4) (The product is for research purpose only.)
Reference
- 1) Pharmacology of the ACAT inhibitor avasimibe (CI-1011) (a review)
- 2) Inhibitors of acyl-coenzyme A: Cholesterol acyltransferase (a review)
- 3) Targeting human Acyl-CoA:cholesterol acyltransferase as dual viral and T cell metabolic checkpoint
- 4) Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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