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CAS RN: 118081-37-1 | Product Number: C3391
Ceftibuten Hydrate
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Purity: >95.0%(HPLC)
Synonyms:
- (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-4-carboxy-1-oxo-2-buten-1-yl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Hydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
89,00 €
|
2 | Ships within 2 months after ordering |
|
|
| 100MG |
258,00 €
|
Contact Us | 3 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | C3391 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__4N__4O__6S__2·xH__2O = 410.42 (as Anhydrous) |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 118081-37-1 |
| Related CAS RN
|
97519-39-6&118081-34-8&118081-35-9 |
| Reaxys Registry Number | 5892046 |
| PubChem Substance ID | 354335681 |
| Merck Index (14) | 1949 |
| MDL Number | MFCD00864918 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation [a]20/D | +135 to +155 deg(C=0.6, 0.1mol/L Potassium phosphate buffer pH8.0(calcd.on anh.substance)) |
| water | 8.0 to 13.0 % |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | 143° (C=1,Phosphate buffer sol.) |
GHS
Related Laws:
| RTECS# | XI0367220 |
Transport Information:
| HS Number | 2941900000 |
Application
Ceftibuten: A Third-Generation β-Lactamase-Stable, Broad-Spectrum Cephalosporin
Ceftibuten (7432-s) is a third-generation cephalosporin that exhibits good antimicrobial activity against many Gram-negative and some Gram-positive organisms. Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall. This binding leads to inhibition of cell-wall synthesis. Especially, ceftibuten has a greater affinity for penicillin-binding protein 3 (PBP 3) more than other cephalosporins. Ceftibuten has a carboxyethylidene substituent at the 7 position, and thereby it is stable against both β-lactamases of Gram-negative bacteria and those mediated by R plasmids. (The product is for research purpose only.)
References
- Ceftibuten - in vitro activity against respiratory pathogens, β-lactamase stability and mechanism of action
- Ceftibuten. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy
- Ceftibuten: An Overview
- Liquid chromatographic determination of ceftibuten, a new oral cephalosporin, in human plasma and urine
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