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CAS RN: 220119-17-5 | Product Number: E1500
Selamectin
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Purity: >95.0%(HPLC)
Synonyms:
- (5Z)-25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A1a
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
€70.00
|
1 | 8 |
|
|
| 1G |
€245.00
|
1 | 9 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | E1500 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__3H__6__3NO__1__1 = 769.97 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 220119-17-5 |
| Reaxys Registry Number | 10756416 |
| MDL Number | MFCD31621085 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
Properties (reference)
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
| RTECS# | CL1199500 |
Transport Information:
| HS Number | 2932209063 |
Application
Selamectin: A Macrocyclic Lactone of the Avermectin Class of Anthelmintics
Selamectin is a macrocyclic lactone of the avermectin class of anthelmintics, which includes ivermectin [I0819].1,2) The mechanism of action of selamectin is not fully understood, but it is strongly suggested to be related to glutamate-gated and GABA-gated chloride channels in nematode muscles and nerves.3,4) Selamectin binds with high affinity to the nematode’s chloride channels. As a result, the nematode is believed to be paralyzed. (The product is for research purpose only.)
References
- 1) Selamectin: a novel broad-spectrum endectocide for dogs and cats (a review)
- 2) Pharmacokinetics of selamectin following intravenous, oral and topical administration in cats and dogs
- 3) Chloride channels as tools for developing selective insecticides (a review)
- 4) Avermectin derivatives, pharmacokinetics, therapeutic and toxic dosages, mechanism of action, and their biological effects (a review)
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