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Published TCIMAIL newest issue No.198
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CAS RN: 118288-08-7 | Product Number: L0341
Lafutidine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (Z)-2-[(Furan-2-ylmethyl)sulfinyl]-N-[4-[[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxy]but-2-en-1-yl]acetamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€17.00
|
Contact Us | 20 |
|
| 250MG |
€102.00
|
1 | 11 |
|
| 1G |
€274.00
|
Contact Us | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0341 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__9N__3O__4S = 431.55 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 118288-08-7 |
| Reaxys Registry Number | 8045494 |
| PubChem Substance ID | 468592156 |
| Merck Index (14) | 5347 |
| MDL Number | MFCD00867520 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 97.0 to 101.0 °C |
Properties (reference)
| Melting Point | 99 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | AC2957000 |
Transport Information:
| HS Number | 2934999090 |
Application
Lafutidine: A Histamine H2 Receptor Antagonist with Gastric Antisecretory and Gastroprotective Activities
Lafutidine (FRG-8813) is a histamine H2 receptor antagonist with gastric antisecretory and gastroprotective activities. It exhibits potent and long-lasting H2 antagonism and prolonged antisecretion. In addition, it shows gastroprotective effects (increased gastric mucosal blood flow and gastric mucus secretion) against gastric mucosal damage through capsaicin-sensitive afferent nerves.
References
- Gastroprotective activity of FRG-8813, a novel histamine H2-receptor antagonist, in rats
- Unique profile of lafutidine, a novel histamine H2-receptor antagonist-mucosal protection throughout gastrointestinal tract mediated by capsaicin-sensitive afferent neurons (a review)
- Determination of lafutidine in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry: Application to a bioequivalence study
- Analytical method development and validation of lafutidine in tablet dosage form by RP-HPLC
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