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CAS RN: 330829-30-6 | Product Number: M3823
MRT-10
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Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- N-[(3-Benzamidophenyl)carbamothioyl]-3,4,5-trimethoxybenzamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€230.00
|
Contact Us | 30 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M3823 |
| Purity / Analysis Method | >98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__4H__2__3N__3O__5S = 465.52 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 330829-30-6 |
| Reaxys Registry Number | 21883721 |
| MDL Number | MFCD02734587 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 164 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2930909599 |
Application
MRT-10: An Orally Bioavailable Small Molecule Inhibitor of Smoothened (Smo)
MRT-10 is an orally bioavailable small molecule inhibitor of Smoothened (Smo) with potential anticancer activity. Smo is a cell surface receptor that mediates sonic hedgehog (Shh) signaling to regulate gene expression through the GLI transcription factors. MRT-10 inhibits the activity of the Shh pathway and prevents tumor growth. (The product is for research use only.)
References
- Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists
- Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity
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