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Published TCIMAIL newest issue No.198
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CAS RN: 52-67-5 | Product Number: P0147
D-Penicillamine
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Purity: >98.0%(T)
Synonyms:
- D-β,β-Dimethylcysteine
- D-β-Mercaptovaline
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€79.00
|
3 | 13 |
|
| 25G |
€390.00
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P0147 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__5H__1__1NO__2S = 149.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 52-67-5 |
| Reaxys Registry Number | 1722375 |
| PubChem Substance ID | 87574400 |
| SDBS (AIST Spectral DB) | 5422 |
| Merck Index (14) | 7088 |
| MDL Number | MFCD00064302 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -61.0 to -65.0 deg(C=1, 1mol/L NaOH sol.) |
| Solubility in Water | almost transparency |
Properties (reference)
| Specific Rotation | -63° (C=1,1mol/L NaOH sol.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 200-148-8 |
| RTECS# | YV9425000 |
Transport Information:
| HS Number | 2930909599 |
Application
D-Penicillamine: A Well-Known Heavy Metal Chelator with Pharmacologic Effects
D-Penicillamine, a hydrolytic degradation product of penicillin-type antibiotics, is a well-known heavy metal chelator. It is used medically as a treatment for medical problems such as Wilson's disease (too much copper in the body), rheumatoid arthritis (RA), cystinuria, and lead poisoning. The pharmacologic effects of D-penicillamine would be associated with formation of penicillamine-cysteine disulfide bond, and metal chelation. Also unlike cytotoxic immunosuppressants which act on both, penicillamine in vitro depresses T-cell activity but not B-cell activity. (The product is for research purpose only.)
References
- Chelation therapy in Wilson's disease: from D-penicillamine to the design of selective bioinspired intracellular Cu(I) chelators
- Chelation therapy in intoxications with mercury, lead and copper
- Analytical profiles of drug substances. Penicillamine
- Determination of thiol by high-performance liquid chromatography and fluorescence detection with 5-methyl-(2-(m-iodoacetylaminophenyl)benzoxazole)
- Simultaneous determination of tiopronin and D-penicillamine in human urine by liquid chromatography with ultraviolet detection
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