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CAS RN: 54-71-7 | Product Number: P0434
Pilocarpine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3-Ethyl-4-[(1-methyl-5-imidazolyl)methyl]tetrahydrofuran-2-one Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
€58.00
|
2 | 8 |
|
|
| 5G |
€228.00
|
5 | ≥100 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | P0434 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__6N__2O__2·HCl = 244.72 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 54-71-7 |
| Reaxys Registry Number | 4034491 |
| PubChem Substance ID | 87574632 |
| Merck Index (14) | 7424 |
| MDL Number | MFCD00012722 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 201.0 to 205.0 °C |
| Specific rotation [a]20/D | +89.0 to +94.0 deg(C=2, H2O) |
| Solubility in Water | almost transparency |
Properties (reference)
| Melting Point | 203 °C |
| Specific Rotation | 92° (C=2,H2O) |
| Solubility (insoluble in) | Ether, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H331 : Toxic if swallowed or if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| EC Number | 200-212-5 |
| RTECS# | TK1450000 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2939800000 |
Application
Pilocarpine Hydrochloride: A Muscarinic Acetylcholine Receptor Agonist
Pilocarpine is an imidazole alkaloid contained in the leaves of Pilocarpus jaborandi and Pilocarpus microphyllus distributed throughout South America. It is a direct acting cholinergic parasympathomimetic agent which acts through direct stimulation of muscarinic acetylcholine receptors (M1, M2, and M3) with low affinity for nicotine receptors. In clinical, formulations of pilocarpine hydrochloride have been used for the treatment of elevated intraocular pressure and dry mouth. (The product is for research purpose only.)
References
- Human M1-, M2- and M3-muscarinic cholinergic receptors: Binding characteristics of agonists and antagonists
- Oral pilocarpine: a review of its pharmacological properties and clinical potential in xerostomia (a review)
PubMed Literature
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