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Published TCIMAIL newest issue No.199
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CAS RN: 94-62-2 | Product Number: P0460
Piperine
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Purity: >97.0%(HPLC)(N)
Synonyms:
- 1-[5-(1,3-Benzodioxol-5-yl)-2,4-pentadienoyl]piperidine
- 1-Piperoylpiperidine
- 1-Piperylpiperidine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€16.00
|
3 | ≥40 |
|
| 5G |
€45.00
|
1 | 13 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P0460 |
Purity / Analysis Method 
|
>97.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__7H__1__9NO__3 = 285.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 94-62-2 |
| Reaxys Registry Number | 90741 |
| PubChem Substance ID | 87574654 |
| SDBS (AIST Spectral DB) | 11113 |
| Merck Index (14) | 7472 |
| MDL Number | MFCD00005839 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 128.0 to 133.0 °C |
Properties (reference)
| Melting Point | 129 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 202-348-0 |
| RTECS# | TN2321500 |
Transport Information:
| HS Number | 2939799090 |
Application
Efflux pump research / Efflux pump inhibitor
Piperine has reported to inhibit efflux pumps in Staphylococcus aureus and Mycobacterium tuberculosis.1-3)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Inhibitory and Resistance-Modifying Potential of Plant-Based Alkaloids Against Methicillin-Resistant Staphylococcus aureus (MRSA)
- 2) Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus
- 3) Piperine as an inhibitor of Rv1258c, a putative multidrug efflux pump of Mycobacterium tuberculosis
- 1) Inhibitory and Resistance-Modifying Potential of Plant-Based Alkaloids Against Methicillin-Resistant Staphylococcus aureus (MRSA)
- 2) Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus
- 3) Piperine as an inhibitor of Rv1258c, a putative multidrug efflux pump of Mycobacterium tuberculosis
- 1) Black pepper and its pungent principle-piperine: A review of diverse physiological effects (a review)
- 2) Piperine: researchers discover new flavor in an ancient spice (a review)
- 3) Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4
- 4) Piper nigrum and Piperine: An Update (a review)
- 5) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
Application
Efflux pump research
Piperine has reported to inhibit efflux pumps in Staphylococcus aureus and Mycobacterium tuberculosis.1-3)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
Application
Piperine: A Natural Piperidine Alkaloid with TRPV1 Activation Ability
Piperine is a natural piperidine alkaloid responsible for the pungency of black pepper. It has been used as a traditional medicine for the treatment of various diseases. The pungency results from activation of the heat- and acidity-sensing TRPV1 ion channels, also known as the capsaicin receptor.1,2) In addition, piperine inhibits P-glycoprotein and/or CYP3A4 which are responsible for the metabolism and transport of xenobiotics and metabolites in the body.3,4) Therefore, piperine has potential to increase bioavailability of other compounds in food and dietary supplements, such as curcumin [C0434][C2302].4,5) (The product is for research purpose only.)
References
PubMed Literature
Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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