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Published TCIMAIL newest issue No.198
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CAS RN: 155213-67-5 | Product Number: R0116
Ritonavir
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Purity: >98.0%(HPLC)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€47.00
|
Contact Us | 12 |
|
| 1G |
€152.00
|
7 | ≥80 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | R0116 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__3__7H__4__8N__6O__5S__2 = 720.95 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 155213-67-5 |
| Reaxys Registry Number | 7680098 |
| PubChem Substance ID | 253660208 |
| Merck Index (14) | 8238 |
| MDL Number | MFCD00927142 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 122.0 to 127.0 °C |
| Specific rotation [a]20/D | +7.0 to +10.0 deg(C=2,MeOH) |
Properties (reference)
| Melting Point | 125 °C |
| Specific Rotation | 8° (C=2,MeOH) |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P261 : Avoid breathing dust. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| RTECS# | XA5310000 |
Transport Information:
| HS Number | 2934100090 |
Application
Ritonavir: a Booster of Other Protease Inhibitors
Ritonavir was originally developed as an inhibitor of HIV protease inhibitor (PI). Ritonavir is currently exclusively used as a pharmacokinetic enhancer (booster) of other protease inhibitors, due to ritonavir's potent inhibition of the cytochrome P 450 3A4 (CYP3A4), an enzyme that is responsible for metabolizing most HIV PIs.
References
- A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease
- A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection
- Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes
- Pharmacokinetic enhancers for HIV drugs
- M. W. Hull, J. S. G. Montaner, Curr. Opin. Invest. Drugs 2009, 10, 775.
- Ritonavir-boosted protease inhibitors in HIV therapy
PubMed Literature
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