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Published TCIMAIL newest issue No.198
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CAS RN: 68373-14-8 | Product Number: S0868
Sulbactam
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid 4,4-Dioxide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€51.00
|
2 | ≥60 |
|
| 25G |
€175.00
|
1 | 14 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0868 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__1__1NO__5S = 233.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 68373-14-8 |
| Reaxys Registry Number | 4192832 |
| PubChem Substance ID | 135727108 |
| Merck Index (14) | 8889 |
| MDL Number | MFCD00867005 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +233.0 to +241.0 deg(C=1, H2O) |
Properties (reference)
| Melting Point | 156 °C(dec.) |
| Specific Rotation | 237° (C=1,H2O) |
| Solubility in water | Soluble |
GHS
Related Laws:
| EC Number | 269-878-2 |
Transport Information:
| HS Number | 2934999090 |
Application
Sulbactam: A β-Lactamase Inhibitor Used with Another Antibiotic
Sulbactam and its sodium salt [U0159] are β-lactamase inhibitors which are chemically synthesized from 6-APA [A0800]. Although they have low antimicrobial activity, they inhibit enzymes (β-lactamases) which are produced by bacteria to degrade β-lactam antibiotics such as penicillins and cephalosporins. They are often used in combination with amoxicillin [A2099] or cefoperazone [C2768] to increase the antibiotic spectrum of theirs. (The product is for research purpose only.)
References
- Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important β-lactamases
- A Structure-Based Analysis of the Inhibition of Class A β-Lactamases by Sulbactam
- Inhibitor-resistant TEM β-lactamases: phenotypic, genetic and biochemical characteristics (a review)
- Understanding the longevity of the β-lactam antibiotics and of antibiotic/β-lactamase inhibitor combinations (a review)
- Current challenges in antimicrobial chemotherapy: focus on β-lactamase inhibition (a review)
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