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Published TCIMAIL newest issue No.198
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CAS RN: 150915-40-5 | Product Number: T3640
Tirofiban Hydrochloride Monohydrate
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Purity: >98.0%(HPLC)
Synonyms:
- N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine Hydrochloride Monohydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€130.00
|
Contact Us | 5 |
|
| 250MG |
€417.00
|
Contact Us | 8 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3640 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__3__6N__2O__5S·HCl·H__2O = 495.08 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 150915-40-5 |
| Related CAS RN
|
144494-65-5&142373-60-2 |
| Reaxys Registry Number | 14636978 |
| PubChem Substance ID | 354335596 |
| Merck Index (14) | 9464 |
| MDL Number | MFCD07368623 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 5.00 to 6.00 % |
| Specific rotation [a]20/D | -12.0 to -16.0 deg(C=1, MeOH) |
| Water | 3.1 to 4.1 % |
Properties (reference)
| Melting Point | 132 °C |
| Specific Rotation | -14° (C=1,MeOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2935909099 |
Application
Tirofiban Hydrochloride: A Nonpeptide Glycoprotein IIb/IIIa Receptor Antagonist
Tirofiban hydrochloride is a reversible antagonist of fibrinogen binding to the platelet glycoprotein (GP) IIb/IIIa receptor, the major platelet surface receptor. GP IIb/IIIa plays a major role in the regulation of platelet adhesion and aggregation during hemostasis, and the GP IIb/IIIa receptor has been identified as the pivotal mediator of platelet aggregation. Therefore, tirofiban hydrochloride specifically inhibits fibrinogen-dependent platelet aggregation and prolongs bleeding times. (The product is for research purpose only.)
References
- Tirofiban: an investigational platelet glycoprotein IIb/IIIa receptor antagonist (a review)
- Glycoprotein IIb/IIIa integrin blockade
- In vitro and in vivo studies on the metabolism of tirofiban
- Integrin αIIbβ3: From Discovery to Efficacious Therapeutic Target
- Determination of Tirofiban in human serum by liquid chromatography-tandem mass spectrometry
- Validated spectrofluorimetric methods for the determination of apixaban and tirofiban hydrochloride in pharmaceutical formulations
PubMed Literature
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