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Published TCIMAIL newest issue No.198
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CAS RN: 165800-06-6 | Product Number: Z0031
Zoledronic Acid Monohydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-Hydroxy-2-(1-imidazolyl)ethane-1,1-diphosphonic Acid Monohydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€47.00
|
2 | 9 |
|
| 5G |
€157.00
|
1 | 8 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | Z0031 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__5H__1__0N__2O__7P__2·H__2O = 290.11 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 165800-06-6 |
| Related CAS RN
|
118072-93-8 |
| Reaxys Registry Number | 9667036 |
| PubChem Substance ID | 253662255 |
| Merck Index (14) | 10187 |
| MDL Number | MFCD00867791 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Water | 5.5 to 8.8 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 245 °C(dec.) |
| Degree of solubility in water | 7 g/l 25 °C |
| Solubility (insoluble in) | Methanol, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. |
Related Laws:
| RTECS# | SZ8562450 |
Transport Information:
| HS Number | 2933299090 |
Application
Bone Resorption Inhibitor
References
- 1)Bisphosphonates: From bench to bedside
- 2)Computational insights into binding of bisphosphates to farnesyl pyrophosphate synthase
- 3)Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite
- 4)Role of zoledronic acid in the prevention and treatment of osteoporosis
- 5)Emerging strategies and therapies for treatment of Paget’s disease of bone
- 6)The use of zoledronic acid, a novel, highly potent bisphosphonate, for the treatment of hypercalcemia of malignancy
PubMed Literature
Documents
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