Reductive Amination

Ramachandran et al. have reported the reductive amination using ammonia borane in the presence of tetraisopropyl orthotitanate. In this method, a variety of aldehydes and ketones react with primary or secondary amines to give the desired secondary or tertiary amines, respectively, in high yields. In addition, primary amines can also be obtained in good yields from ketones using NH₄Cl as the ammonia source.