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Published TCIMAIL newest issue No.198
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CAS RN: 56-12-2 | Product Number: A0282
4-Aminobutyric Acid
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Purity: >99.0%(T)
Synonyms:
- GABA
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 25G |
€17.00
|
16 | ≥60 |
| 100G |
€36.00
|
4 | 6 |
| 500G |
€114.00
|
4 | ≥100 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A0282 |
| Purity / Analysis Method | >99.0%(T) |
| Molecular Formula / Molecular Weight | C__4H__9NO__2 = 103.12 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 56-12-2 |
| Reaxys Registry Number | 906818 |
| PubChem Substance ID | 87561936 |
| SDBS (AIST Spectral DB) | 1075 |
| Merck Index (14) | 430 |
| MDL Number | MFCD00008226 |
Specifications
| Appearance | White powder to crystaline |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Solubility in Water | almost transparency |
Properties (reference)
| Melting Point | 195 °C(dec.) |
GHS
Related Laws:
| EC Number | 200-258-6 |
| RTECS# | ES6300000 |
Transport Information:
| HS Number | 2922498590 |
Application
GABA: A Major Inhibitory Neurotransmitter in Nervous System
4-Aminobutyric acid (γ-aminobutyric acid or GABA) is a major inhibitory neurotransmitter in nervous system, the first report by Hayashi et al. in 1950s. GABA is present not only in the central nervous system but also in the peripheral nervous system. GABA plays the principal role in modulating neuronal excitability throughout the nervous system. Moreover, GABA is involved in a variety of biological functions such as proliferation, differentiation, migration and growth of neurons. GABA functions appear to be triggered by binding of GABA to its ionotropic receptors (GABAA and GABAC) which are ligand-gated chloride channels, and its metabotropic receptors GABAB which are coupled to G-proteins.
References
- Inhibition and excitation due to gamma-aminobutyric acid in the central nervous system.
- Excitatory actions of GABA during development: the nature of the nurture (a review)
- GABA and GABA receptors in the central nervous system and other organs (a review)
- GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations (a review)
- Extracellular level of GABA and Glu: in vivo microdialysis-HPLC measurements
- Determination and Comparison of γ-Aminobutyric Acid (GABA) Content in Pu-erh and Other Types of Chinese Tea
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