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Published TCIMAIL newest issue No.199
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CAS RN: 957-68-6 | Product Number: A1266
7-Aminocephalosporanic Acid
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Purity: >97.0%(T)(HPLC)
Synonyms:
- 7-ACA
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€16.00
|
1 | 24 |
| 25G |
€45.00
|
6 | 26 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A1266 |
Purity / Analysis Method 
|
>97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__2N__2O__5S = 272.28 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 957-68-6 |
| PubChem Substance ID | 87562732 |
| Merck Index (14) | 434 |
| MDL Number | MFCD00005177 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation [a]20/D | +88.0 to +94.0 deg(C=0.5, buffer sol.pH7.0 KH2PO4) |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | 90° (C=0.5,buffer sol. pH7.0 KH2PO4) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P284 : Wear respiratory protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. |
Related Laws:
| EC Number | 213-485-0 |
Transport Information:
| HS Number | 2941100000 |
Application
7-Aminocephalosporanic Acid (7-ACA): a Starting Compound for Semisynthetic Cephalosporin Antibiotics.
The enzymatic conversion of cephalosporin C gives 7-aminocephalosporanic acid (7-ACA) [A1266], which is used as a starting compound for semisynthetic cephalosporin antibiotics. Modification of 7-ACA at the 3- and 7-positions gives rise to a number of third and fourth semisynthetic cephalosporin antibiotics that are significantly generally more active against Gram-negative bacteria than first and second generation ones. Differences in side chain structure at the 7-position directly affect their antibiotic activity, whereas modifications made at the 3-position influence their metabolism and pharmacokinetic properties of the drugs.
References
- Development of the semi-synthetic penicillins and cephalosporins
- Enzymatic Deprotection of the Cephalosporin 3’-Acetoxy Group Using Candida antarctica Lipase B
- Synthesis and antibacterial properties of 7-[2-(3-substituted-5-isoxazolyl)-2-methoxyiminoacetamidojcephalosporanic acid derivatives
- Synthesis and biological activity of novel 3-(2-propenyl)-cephalosporins. I.
- Studies on orally active cephalosporinsi. Synthesis and structure-activity relationships of new 3-substituted carbamoyloxymethyl cephalosporins
- Antimicrobial Agents: Antibacterials and Antifungals (a book review)
PubMed Literature
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