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CAS RN: 7177-48-2 | Product Number: A2092
Ampicillin Trihydrate
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- D-(-)-α-Aminobenzylpenicillin Trihydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 5G |
16,00 €
|
≥40 | 22 | |
| 25G |
41,00 €
|
6 | Ships within 3-4 months after ordering |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | A2092 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__9N__3O__4S·3H__2O = 403.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 7177-48-2 |
| Related CAS RN
|
69-53-4 |
| Reaxys Registry Number | 5399534 |
| PubChem Substance ID | 87560211 |
| Merck Index (14) | 586 |
| MDL Number | MFCD00072036 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +280 to +305 deg(C=0.5, H2O)(calcd.on anh.substance) |
| Water | 12.0 to 15.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 202 °C(dec.) |
| Specific Rotation | 293° (C=0.5,H2O) |
| Degree of solubility in water | 10 g/l 21 °C |
| Solubility (insoluble in) | Chloroform, Ether, Benzene |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H362 : May cause harm to breast-fed children. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. |
Related Laws:
| RTECS# | XH8425000 |
Transport Information:
| HS Number | 2941100000 |
Application
Biofilm research
Susceptibility of Actinobacillus actinomycetemcomitans, strain 310a, biofilm to ampicillin has been reported.1) Adding 10 mg/L of the antibiotic significantly inhibited the biofilm formation in the early phase, but not in the mature phase.
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- Susceptibility of Actinobacillus actinomycetemcomitans to six antibiotics decreases as biofilm matures
- Ampicillin [D-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid] (a review)
- Sulbactam/ampicillin. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic use
- Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections
- Construction and characterization of new cloning vehicle. II. A multipurpose cloning system
Application
Ampicillin: The First of Broad Spectrum Penicillins
Ampicillin, a penicillin-like antibiotic, is enzymatic synthesized from 6-APA [A0800] catalyzed by penicillin acylase. Ampicillin is the first of a number of so-called broad spectrum penicillins. That amino group helps the drug penetrate the outer membrane of Gram-negative bacteria. Thus, ampicillin has activity against not only Gram-positive bacteria such as Staphylococci and Streptococci but also Gram-negative bacteria such as H. influenzae, coliforms and Proteus species. It acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Its spectrum of activity is enhanced by co-administration of sulbactam [S0868], a drug that inhibits beta lactamase an enzyme produced by bacteria to inactivate ampicillin. Ampicillin is used in molecular biology as a selective reagent most commonly to isolate bacteria coupled to a gene coding for ampicillin resistance, which is one of the most frequently used selection markers for obtaining transgenic cells.
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