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Published TCIMAIL newest issue No.201
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CAS RN: 63968-64-9 | Product Number: A2118
Artemisinin
×
Purity: >97.0%(HPLC)
Synonyms:
- Arteannuin
- Qinghaosu
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 1G |
€39.00
|
2 | 8 | |
| 5G |
€126.00
|
2 | 10 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | A2118 |
Purity / Analysis Method 
|
>97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__2O__5 = 282.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 63968-64-9 |
| Reaxys Registry Number | 4194670 |
| PubChem Substance ID | 87560451 |
| Merck Index (14) | 817 |
| MDL Number | MFCD00081057 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Melting point | 151.0 to 155.0 °C |
| Specific rotation [a]20/D | +70.0 to +80.0 deg(C=0.5, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 153 °C |
| Specific Rotation | 75° (C=0.5,MeOH) |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
| RTECS# | KD4170000 |
Transport Information:
| HS Number | 2932990090 |
Application
Artemisinin: An Antimalarial Sesquiterpene Lactone
Artemisinin is a fast-acting and widely used antimalarial agent. Artemisinin was first isolated in 1971 from Chinese medicinal herb Artemisia annua by Tu, a Chinese scientist, who was awarded the Nobel Prize in Physiology or Medicine with Omura and Campbell in 2015. After the activity of artemisinin had been established, several analogs such as such as artemether [A2190], artesunate [A2191] and dihydroartemisinin [D3793] were developed to improve bioavailability and efficacy. Artemisinin and its analogs have high efficacy against Plasmodium falciparum in the blood stages of the disease. The exact mechanism of action is still not clear, while the endoperoxide (O-O) subunit of the trioxane ring is critical for antimalarial activity. Several lines of evidence indicate that the O-O bond is easily broken by Fe2+, generating a number of reactive radicals oxidatively damage parasite. (The product is for research purpose only.)
References
- Qinghaosu (artemisinin): an antimalarial drug from China (a review)
- Artemisinin: mechanisms of action, resistance and toxicity (a review)
- Antimalarial activity of mefloquine and qinghaosu
- Total synthesis of qinghaosu
- The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
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