Maintenance Notice (12:30 AM - 5:30 AM August 24, 2025): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.198
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 58713-03-4 | Product Number: A2555
5-Acetyl-1,3-dimethylbarbituric Acid
×
![]()
×
Purity: >98.0%(GC)(T)
Synonyms:
- DAB
- 1,3-Dimethyl-5-acetylbarbituric Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
162,00 €
|
1 | 22 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2555 |
Purity / Analysis Method 
|
>98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__8H__1__0N__2O__4 = 198.18 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 58713-03-4 |
| Reaxys Registry Number | 196385 |
| PubChem Substance ID | 172089124 |
| MDL Number | MFCD00218518 |
Specifications
| Appearance | White to Light yellow powder to crystalline |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 99 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
Related Laws:
Transport Information:
| HS Number | 2933540000 |
Application
Selective Protection and Deprotection of Primary Amino Group Using 1,3-Dimethyl-5-acetylbarbituric Acid
Typical Procedure 1: Primary amino group selective protection using DAB
A solution of (1R,2R)-1,2-diphenylethanediamine (1.06 g, 5.0 mmol) and 1,3-dimethyl-5-acetylbarbituric acid (DAB) (1) (991 mg, 5 mmol) in anhydrous THF (15 mL) is stirred at room temperature under Ar. After stirring for 48 h, the reaction mixture is concentrated under reduced pressure, and the residue is purified by column chromatography using neutral silica gel (n-hexane:ethyl acetate=1:1) to afford the product 2 (1.92 g, 98% yield).
A solution of (1R,2R)-1,2-diphenylethanediamine (1.06 g, 5.0 mmol) and 1,3-dimethyl-5-acetylbarbituric acid (DAB) (1) (991 mg, 5 mmol) in anhydrous THF (15 mL) is stirred at room temperature under Ar. After stirring for 48 h, the reaction mixture is concentrated under reduced pressure, and the residue is purified by column chromatography using neutral silica gel (n-hexane:ethyl acetate=1:1) to afford the product 2 (1.92 g, 98% yield).
Typical Procedure 2: Primary amino group selective deprotection using DAB
A solution of 3 (196 mg, 0.396 mmol) and 2-aminoethanol (238 µL, 3.96 mmol) in anhydrous EtOH (3 mL) is stirred at 50 °C for 24 h under Ar. After removal of the solvent under reduced pressure, the residue is purified by column chromatography using neutral silica gel (n-hexane:ethyl acetate=1:1) to afford the product 4 (124 mg, 99% yield).
A solution of 3 (196 mg, 0.396 mmol) and 2-aminoethanol (238 µL, 3.96 mmol) in anhydrous EtOH (3 mL) is stirred at 50 °C for 24 h under Ar. After removal of the solvent under reduced pressure, the residue is purified by column chromatography using neutral silica gel (n-hexane:ethyl acetate=1:1) to afford the product 4 (124 mg, 99% yield).
References
PubMed Literature
Documents
Product Articles
[Product Highlights] Selective Protection and Deprotection of Primary Amino Group Using 1,3-Dimethyl-5-acetylbarbituric AcidProduct Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.