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CAS RN: 54301-15-4 | Product Number: A2777
Amsacrine Hydrochloride
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine Hydrochloride
- m-AMSA
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 100MG |
€ 141,00
|
1 | 10 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | A2777 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__1H__1__9N__3O__3S·HCl = 429.92 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 54301-15-4 |
| Related CAS RN
|
51264-14-3 |
| Reaxys Registry Number | 5692112 |
| PubChem Substance ID | 354333613 |
| MDL Number | MFCD07799963 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 288 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H351 : Suspected of causing cancer. |
| Precautionary Statements | P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| RTECS# | PB1081000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2935909099 |
Application
Amsacrine: A DNA Intercalator with the Inhibition of Topoisomerase II
Amsacrine (known as m-AMSA) hydrochloride is an acridine derivative that has a potent antitumor activity against leukemic cells. Amsacrine inhibits topoisomerase II which is a group of essential enzymes for DNA replication with important functions for DNA function and cell survival. Topoisomerase II is now viewed as an important cellular target of antitumor drugs including both DNA intercalators (amsacrine and doxorubicin [D4193]) and the nonintercalator epipodophyllotoxin derivatives (etoposide [E0675] and teniposide [T3109]). Amsacrine is often used in combination with other chemotherapy drugs to treat types of adult leukemia, particularly acute myeloid leukemia (AML). (The product is for research purpose only.)
References
- Quenching of DNA-ethidium fluorescence by amsacrine and other antitumor agents: a possible electron-transfer effect
- Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)methanesulfon-m-anisidide
- The mechanism of action of mAMSA (a review)
- DNA topoisomerase-targeting antitumor drugs can be studied in yeast
- The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents
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