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Published TCIMAIL newest issue No.201
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CAS RN: 84692-91-1 | Product Number: A3449
Arglabin
×
Purity: >98.0%(HPLC)
Synonyms:
- (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-Hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 5MG |
€284.00
|
1 | 4 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | A3449 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__8O__3 = 246.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 84692-91-1 |
| Reaxys Registry Number | 3549528 |
| PubChem Substance ID | 468590304 |
| MDL Number | MFCD11519463 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | +101 to +104 deg (C=0.3, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 102 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2932209090 |
Application
Arglabin: A Natural NLRP3 Inhibitor
Arglabin, a sesquiterpene γ-lactone, is originally extracted from Artemisia glabella, and also is found in Artemisia myiantha (a species of wormwood) which is a plant commonly used in traditional Chinese medicine.1,2) Arglabin and its derivatives have been reported as NLR family pyrin domain-containing protein 3 (NLRP3) inflammasome inhibitors which show anti-inflammatory antitumor, and antiviral (including anti-SARS-CoV-2) activities.2-5) The antitumor activity of arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene.2) (The product is for research purpose only.)
References
- 1) In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall. (Asteraceae).
- 2) Arglabin: From isolation to antitumor evaluation (a review)
- 3) Sesquiterpene lactones from Artemisia Genus: biological activities and methods of analysis (a review)
- 4) Chemical modification of arglabin and biological activity of its new derivatives (a review)
- 5) Targeting the NLRP3 inflammasome in severe COVID-19 (a review)
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