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Published TCIMAIL newest issue No.198
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CAS RN: 125316-60-1 | Product Number: A3612
CD 437
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Purity: >93.0%(qNMR)
Synonyms:
- AHPN
- 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic Acid
- 6-[4-Hydroxy-3-[tricyclo[3.3.1.13,7]decan-1-yl]phenyl]-2-naphthoic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 10MG |
€200.00
|
Contact Us | 19 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3612 |
| Purity / Analysis Method | >93.0%(qNMR) |
| Molecular Formula / Molecular Weight | C__2__7H__2__6O__3 = 398.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 125316-60-1 |
| Reaxys Registry Number | 7445028 |
| MDL Number | MFCD03106506 |
Specifications
| Appearance | White to Light gray to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 93.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 275 °C |
GHS
Related Laws:
| RTECS# | QJ1975900 |
Transport Information:
| HS Number | 2918290090 |
Application
CD 437: A Selective Retinoic Acid Receptor (RARγ) Agonist
CD 437 (AHPN) is a synthetic retinoid-like small molecule that is a selective retinoic acid receptor (RARγ) agonist. There are reports that CD 437 selectively induces apoptosis in cancer cells.1-4) In addition, CD 437 has been reported to show significant efficacy in a mouse model of chronic MRSA infection.5) (The product is for research purpose only.)
References
- 1) p53 Independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells
- 2) Classical and novel retinoids: Their targets in cancer therapy (a review)
- 3) Targeting Nur77 translocation (a review)
- 4) The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α
- 5) A new class of synthetic retinoid antibiotics effective against bacterial persisters
Product Documents (Note: Some products will not have analytical charts available.)
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